In order to run MPC-HC you must have an SSE capable CPU. MPC-HC will work on Windows® XP Service Pack 3, Vista, 7 and 8, both 32-bit (x86) and 64-bit (x64).
Try updating your video card drivers.
You have accidentally enabled D3D Fullscreen, go to Options -> Output and disable the D3D Fullscreen checkbox.
The video display is experiencing a synchronisation issue, try enabling V-Sync by pressing V. If you have more than one monitor connected make sure you extend the screen instead of duplicating it.
Hardware acceleration is most likely not working correctly. Try going to Options -> Internal Filters, right-click the list on the right and click “Disable DXVA filters” and then reload the video file. If this does not solve and your video file plays correctly in other video players then please make a bug report.
Supporting these new platforms require a lot of changes and this is simply not possible for us in the near future, with the current manpower.